By Sinéad Carew, Devik Jain and Anisha Sircar (Reuters) – Wall Street’s three major indexes closed lower on Wednesday as investors bet that the latest economic data would do nothing to push the Federal Reserve off track from its aggressive interest rate hiking cycle aimed at taming run-away inflation. Data showed that while U.S. job openings fell in April, they remained at high levels, suggesting continued wage increases contributing to uncomfortably high inflation as companies scramble for workers. Also U.S. manufacturing activity picked up pace faster than expected in May as demand for goods…